反应 #1994258

反应方程式

10-(biphenyl-4-yl)-9,10-dihydroacridine

bromosuccinimide

→

10-(biphenyl-4-yl)-2-bromo-9,10-dihydroacridine

收率 77.7%

溶剂

chloroform

反应条件

后处理

1. 1
   洗涤the resultant solution was washed with distilled water
2. 2
   萃取Then, an organic layer was extracted
3. 3
   干燥dried with sodium sulfate so as
4. 4
   其他to remove the solvent
5. 5
   其他The residue was purified by silica gel column chromatography (methylene chloride/n-hexane (1/20))

实验过程

The obtained 10-(biphenyl-4-yl)-9,10-dihydroacridine (15.3 g, 45.9 mmol) was added with chloroform (500 ml), and then with bromosuccinimide (9.8 g, 55.1 mmol). The resultant solution was stirred at room temperature for 2 hours. After the reaction was completed, the resultant solution was washed with distilled water. Then, an organic layer was extracted and dried with sodium sulfate so as to remove the solvent. The residue was purified by silica gel column chromatography (methylene chloride/n-hexane (1/20)) to obtain 10-(biphenyl-4-yl)-2-bromo-9,10-dihydroacridine compound (white solid, 14.7 g, yield 77%).

来源