反应 #1994256

反应方程式

LiAlH4

acridine

sodium bicarbonate

→

9,10-dihydroacridine

收率 82.0%

溶剂

THF

反应条件

后处理

1. 1
   萃取extracted with methylene chloride
2. 2
   workup.DISTILLATIONdistilled water
3. 3
   干燥The extracted layer was dried with sodium sulfate so as to filtrate
4. 4
   浓缩concentrate an organic solvent

实验过程

Under a nitrogen atmosphere, acridine (17.19 g, 95.92 mmol) and THF (300 ml) were introduced into a round-bottom flask. At 0° C., LiAlH4 (14.56 g, 383.66 mmol) was slowly added in halves twice thereto, followed by stirring at room temperature for 4 hours. At 0° C., the resultant product was slowly added with a sodium bicarbonate solution, and then extracted with methylene chloride and distilled water. The extracted layer was dried with sodium sulfate so as to filtrate and concentrate an organic solvent. Then, the resultant product was columned by methylene chloride and hexane (n-Hexane:MC=8:2) so as to obtain a required compound, 9,10-dihydroacridine (white solid, 14 g, 82%).

来源