反应 #1994252

反应方程式

water

carbazole

sodium hydroxide

allylbromide

→

N-Allylcarbazole

溶剂

dimethylsulfoxide

反应条件

后处理

1. 1
   萃取extracted with ethyl acetate
2. 2
   洗涤The ethyl acetate layer was washed with water
3. 3
   浓缩concentrated
4. 4
   其他The crude product was purified

实验过程

A mixture of 10.85 g (65.0 mmol) of carbazole, 2.60 g (65.0 mmol) of sodium hydroxide and 6.1 mL (72.0 mmol) of allylbromide in 100 mL dimethylsulfoxide was heated to 60° C. for 5 hours. The reaction mixture was poured into water and extracted with ethyl acetate. The ethyl acetate layer was washed with water and then concentrated. The crude product was purified using column chromatography (silica, 1:4 dichloromethane:hexane). Yield: 9.85 g (73%).

来源