反应 #1994236

反应方程式

hydrocodone Bitartrate

→

Hydrocodone

溶剂

water

反应条件

后处理

1. 1
   workup.ADDITIONslowly adding 1,407 g of AMBERLITE™
2. 2
   workup.ADDITIONThe dispersion was mixed for 4 hours and upon completion
3. 3
   其他before decanting the supernatant
4. 4
   其他The wet resin complex was then dried in a VWR™ convection oven
5. 5
   workup.ADDITIONKOLLICOAT™ SR-30D polymer (500 g) was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid)
6. 6
   其他to form a uniform mass
7. 7
   其他The wet mass was again dried in a 50° C
8. 8
   其他The semi-dried granules were then milled through a 40 mesh screen
9. 9
   其他continued drying under 50° C. until the moisture content
10. 10
    其他The dried granules were then milled through a 40 mesh screen

实验过程

The Hydrocodone Resin Complex was prepared by first dissolving 450 g of hydrocodone Bitartrate in 8 kg of purified water, and then slowly adding 1,407 g of AMBERLITE™ IRP-69 resin with continuous mixing. The dispersion was mixed for 4 hours and upon completion, allowed to settle before decanting the supernatant. The slurring/decanting process was repeated twice with sufficient amounts of purified water. The wet resin complex was then dried in a VWR™ convection oven maintained at 50° C. until moisture content was about 20-25%. KOLLICOAT™ SR-30D polymer (500 g) was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid) to form a uniform mass. The wet mass was again dried in a 50° C. VWR™ convection oven to the moisture content around 15-20%. The semi-dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill and continued drying under 50° C. until the moisture content was between 3-7%. The dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill.

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