反应 #1994234

反应方程式

pseudoephedrine HCl

→

Pseudoephedrine

溶剂

water

反应条件

后处理

1. 1
   workup.ADDITIONslowly adding 1,589 g of AMBERLITE™
2. 2
   workup.ADDITIONThe dispersion was mixed for 4 hours and upon completion
3. 3
   其他before decanting the supernatant
4. 4
   过滤The slurry was filtered
5. 5
   洗涤rinsed 3 times with sufficient amounts of purified water
6. 6
   其他The wet resin complex was then dried in a VWR™ convection oven
7. 7
   workup.ADDITIONKOLLICOAT™ SR-30D polymer (668 g) was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid)
8. 8
   其他to form a uniform mass
9. 9
   其他The wet mass was again dried at 50° C. in a VWR™ convection oven to the moisture content around 30%
10. 10
    其他The semi-dried granules were then milled through a 40 mesh screen
11. 11
    其他continued drying under 50° C. until the moisture content
12. 12
    其他The dried granules were then milled through a 40 mesh screen

实验过程

The Pseudoephedrine Resin Complex was prepared by first dissolving 857 g of pseudoephedrine HCl in 5 liter of purified water, and then slowly adding 1,589 g of AMBERLITE™ IRP-69 resin with continuous mixing. The dispersion was mixed for 4 hours and upon completion, allowed to settle before decanting the supernatant. The slurry was filtered and rinsed 3 times with sufficient amounts of purified water. The wet resin complex was then dried in a VWR™ convection oven maintained at 50° C. until moisture content was about 25%. KOLLICOAT™ SR-30D polymer (668 g) was then slowly added to the wet resin complex in a Hobart type mixer (Kitchen Aid) to form a uniform mass. The wet mass was again dried at 50° C. in a VWR™ convection oven to the moisture content around 30%. The semi-dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill and continued drying under 50° C. until the moisture content was between 4-6%. The dried granules were then milled through a 40 mesh screen using CO-MIL™ brand mill.

来源