反应 #1994226

反应方程式

Boc-Gly Rotigotine HCl

trifluoroacetic acid

→

Gly Rotigotine

收率 79.0%

溶剂

dichloromethane

反应条件

后处理

1. 1
   其他all the volatiles were removed
2. 2
   其他a rotary evaporator
3. 3
   workup.DISSOLUTIONThe residue (dark yellow) was dissolved in methanol
4. 4
   其他precipitated
5. 5
   workup.ADDITIONby adding into diethyl ether (40 mL)
6. 6
   过滤The pale yellow precipitate was filtered
7. 7
   其他dried

实验过程

The Boc-Gly-Rotigotine HCl was deprotected by first dissolving the product (1.258 g, 2.55 mmol) in dichloromethane (64 ml). After addition of trifluoroacetic acid (9.83 ml, 128 mmol), the reaction mixture was stirred for 1 hour at room temperature and then all the volatiles were removed using a rotary evaporator. The residue (dark yellow) was dissolved in methanol and precipitated by adding into diethyl ether (40 mL). The pale yellow precipitate was filtered using a glass frit and dried to give Gly-Rotigotine.2TFA (1.140 g, 79% yield).

来源