反应 #1985941

反应方程式

bromine

4-acetoxy-3-methoxybenzaldehyde

sodium acetate

iodine

→

desired product

4-Acetoxy-6-bromo-3-methoxybenzaldehyde

溶剂

water

acetic acid

反应条件

后处理

1. 1
   workup.STIRRINGstirred at room temperature for 3 days
2. 2
   过滤filtered
3. 3
   workup.DISSOLUTIONThe solid is dissolved in toluene
4. 4
   洗涤the solution washed with brine
5. 5
   干燥dried over magnesium sulfate
6. 6
   过滤filtered
7. 7
   浓缩concentrated in vacuo
8. 8
   其他The residue is recrystallized twice from hexanes

实验过程

To a mixture of 4-acetoxy-3-methoxybenzaldehyde (75.7 g), anhydrous sodium acetate (76 g) and iodine (0.8 g) in acetic acid (300 ml) is added bromine (21 ml). The mixture is warmed to 45° C. for about 1 hour, then stirred stirred at room temperature for 3 days, poured into water (700 ml) and filtered. The solid is dissolved in toluene and the solution washed with brine, dried over magnesium sulfate, filtered and concentrated in vacuo. The residue is recrystallized twice from hexanes to give the desired product.

来源