反应 #1985937

反应方程式

ammonium hydroxide

bis-[5-(2-methoxycarbonylethyl)-3-[5-(2-methoxycarbonylethyl)-2-hydroxybenzyl]2-hydroxyphenyl]methane

sodium hydroxide

→

desired product

Bis-[5-(2-carboxyethyl)-3-[5-(2-carboxyethyl)-2-hydroxybenzyl]2-hydroxyphenyl]methane

溶剂

methanol

反应条件

后处理

1. 1
   其他The mixture is quenched with dilute aqueous hydrochloric acid (HCl)
2. 2
   其他The mixture is quenched as above and the organic soluble material flash
3. 3
   其他chromatographed
4. 4
   洗涤eluting with 10% methanol in chloroform
5. 5
   其他The product so obtained

实验过程

A solution of bis-[5-(2-methoxycarbonylethyl)-3-[5-(2-methoxycarbonylethyl)-2-hydroxybenzyl]2-hydroxyphenyl]methane (0.10 g) in methanol (2 ml) is stirred with 10% aqueous sodium hydroxide (NaOH) (1 ml) at room temperature. The mixture is quenched with dilute aqueous hydrochloric acid (HCl) and the organic soluble material retreated as above. The mixture is quenched as above and the organic soluble material flash chromatographed, eluting with 10% methanol in chloroform. The product so obtained is treated with ammonium hydroxide solution and lyophilized to give the desired product as the ammonium salt, m.p. 150° C. (dec.).

来源