反应 #1983208

反应方程式

compound

4-{4-[3-(6-Methylpyridin-2-yl)prop-2-yn-1-ylidene]piperidin-1-yl}isoquinoline

5-bromo-2-ethoxypyridine

tol-BINAP

→

title compound

收率 10.0%

2-Ethoxy-5-{4-[3-(6-methylpyridin-2-yl)prop-2-ynylidene]piperidin-1-yl}pyridine

收率 10.0%

反应条件

实验过程

Following the procedure reported for the compound of Example 234 and using 5-bromo-2-ethoxypyridine instead of 4-bromoisoquinoline and tol-BINAP (2,2′-bis(di-p-tolylphosphino)-1,1′-binaphthyl) instead of BINAP the title compound was prepared. After the work-up, the residue was purified by automated flash liquid chromatography (Horizon™-Biotage) eluting with PE-EtOAc 8:2. affording the title product as a yellow oil. Yield: 10%.

来源