反应 #1973967

反应方程式

2-hydroxy-3,5-diiodobenzoic acid

dimethyl sulfate

acetone

→

solid

methyl 3,5-diiodo-2-methoxybenzoate

反应条件

后处理

1. 1
   温度was heated
2. 2
   温度at reflux for 16 h
3. 3
   温度cooled
4. 4
   浓缩concentrated
5. 5
   workup.DISSOLUTIONThe residue was dissolved in EtOAc
6. 6
   洗涤washed with water, brine
7. 7
   干燥dried (Na2SO4)
8. 8
   过滤filtered
9. 9
   浓缩concentrated

实验过程

A mixture of 2-hydroxy-3,5-diiodobenzoic acid (3.9 g, 10.0 mmol) potassium carbonate (4.15 g, 30.0 mmol) and dimethyl sulfate (2.77 g, 22.0 mmol) in acetone (33 ml) was heated at reflux for 16 h, cooled and concentrated. The residue was dissolved in EtOAc and washed with water, brine, dried (Na2SO4), filtered and concentrated to give an off-white solid (4.2 g, quantitative yield).

来源