反应 #1973961

反应方程式

Methyl 3-tert-butyl-2-methoxy-5-nitrobenzoate

ammonium chloride

water

→

title compound

收率 100.0%

methyl 5-amino-3-tert-butyl-2-methoxybenzoate

收率 100.0%

溶剂

methanol

反应条件

后处理

1. 1
   过滤filtered through celite
2. 2
   洗涤the celite washed with methanol
3. 3
   浓缩The filtrate was then concentrated under vacuum
4. 4
   workup.DISSOLUTIONdissolved in ethyl acetate (600 mL)
5. 5
   洗涤The resultant solution was then washed with water and brine
6. 6
   萃取The organic extract
7. 7
   其他was then dried
8. 8
   过滤filtered
9. 9
   浓缩concentrated under vacuum

实验过程

Methyl 3-tert-butyl-2-methoxy-5-nitrobenzoate (10.42 g, 39.0 mmol), iron powder (325 mesh, 10.89 g, 195 mmol), ammonium chloride (3.13 g, 58.5 mmol), water (30 mL), and methanol (150 mL) were added together. The resultant mixture was then refluxed for 1 h. The mixture was then cooled to room temperature, filtered through celite, and the celite washed with methanol. The filtrate was then concentrated under vacuum and dissolved in ethyl acetate (600 mL). The resultant solution was then washed with water and brine. The organic extract was then dried, filtered and concentrated under vacuum to yield the title compound as an oil (9.25 g, 100%).

来源