反应 #1973924

反应方程式

Bupivacaine hydrochloride

sodium hydroxide

→

Bupivacaine

溶剂

water

反应条件

后处理

1. 1
   其他to precipitate the Bupivacaine base
2. 2
   过滤The precipitated product was filtered
3. 3
   洗涤further washed with DI water for at least three times
4. 4
   其他The precipitated product was dried at ca. 40° C. in vacuum for 24 hours

实验过程

Bupivacaine hydrochloride (Sigma-Aldrich Corporation, St. Louis, Mo.) was dissolved in de-ionized (DI) water at a concentration of 40 mg/ml (saturation). A calculated amount of sodium hydroxide (in the form of 1 N solution) was added to the solution and the pH of the final mixtures was adjusted to ten to precipitate the Bupivacaine base. The precipitated product was filtered, and further washed with DI water for at least three times. The precipitated product was dried at ca. 40° C. in vacuum for 24 hours.

来源