反应 #1960484

反应方程式

2,3-difluorophenol

propargyl bromide

potassium carbonate

→

1,2-difluoro-3-prop-2-ynyloxybenzene

溶剂

ethyl methyl ketone

反应条件

后处理

1. 1
   过滤The batch is filtered
2. 2
   洗涤the filter residue is washed with MTBE
3. 3
   其他The filtrate is evaporated to dryness
4. 4
   其他the residue is purified by column chromatography (SiO2, n-heptane:MTBE=3:1)

实验过程

115.0 g (0.88 mol) of 2,3-difluorophenol are refluxed for 3 h in 1.6 l of ethyl methyl ketone together with 118.2 ml (17.7 mol) of propargyl bromide (80% soln. in toluene) and 146.6 g (138.2 mol) of potassium carbonate. The batch is filtered, and the filter residue is washed with MTBE. The filtrate is evaporated to dryness, and the residue is purified by column chromatography (SiO2, n-heptane:MTBE=3:1).

来源