反应 #1951057

反应方程式

Bromotrimethylsilane

(4-fluoro-benzyl)-phosphonic acid dimethyl ester

→

(4-fluoro-benzyl) phosphonic acid bis(trimethylsilyl) ester

反应条件

后处理

1. 1
   温度to warm to ambient temperature
2. 2
   workup.STIRRINGstirred for an additional hour
3. 3
   浓缩concentrated by rotary evaporation
4. 4
   其他to remove volatiles

实验过程

Bromotrimethylsilane (6.0 mL, 45.4 mmol) was added dropwise to (4-fluoro-benzyl)-phosphonic acid dimethyl ester (4.57 g, 20.95 mmol) and stirred in a reaction flask chilled to 0° C. The resulting solution was allowed to warm to ambient temperature and stirred for an additional hour, then concentrated by rotary evaporation to remove volatiles yielding crude (4-fluoro-benzyl) phosphonic acid bis(trimethylsilyl) ester which was used without further purification.

来源