反应 #1951042

反应方程式

tetrabutylammonium fluoride

acetic acid

Compound 22

5′-O-t-butyldimethylsilyl-2′,3′-dideoxy-4′-C-triethylsilylethynyl-2-fluoroadenosine

→

2′,3′-dideoxy-4′-C-ethynyl-2-fluoroadenosine

溶剂

tetrahydrofuran

tetrahydrofuran

反应条件

后处理

1. 1
   其他reaction mixture
2. 2
   浓缩the resultant mixture was concentrated under reduced pressure
3. 3
   其他The thus-obtained residue was purified by means of silica gel column chromatography (silica gel 15 ml, chloroform:methanol=40:1 to 20:1)

实验过程

Compound 22 (101 mg, 0.200 mmol) was dissolved in tetrahydrofuran (10 ml), and a solution of 1-M tetrabutylammonium fluoride in tetrahydrofuran (0.42 ml, 0.42 mmol) was added to the resultant solution, followed by stirring at room temperature for five minutes. After acetic acid (24 μl) was added to the resultant reaction mixture, the resultant mixture was concentrated under reduced pressure. The thus-obtained residue was purified by means of silica gel column chromatography (silica gel 15 ml, chloroform:methanol=40:1 to 20:1), to thereby yield compound 23 (53.0 mg, 0.191 mmol, 95.7%).

来源