反应 #1951041

反应方程式

ammonia

Compound 7

3′,5′-di-O-acetyl-4′-C-cyano-2′-deoxy-2-fluoroadenosine

→

4′-C-cyano-2′-deoxy-2-fluoroadenosine

溶剂

methanol

反应条件

后处理

1. 1
   其他The resultant reaction mixture
2. 2
   浓缩was concentrated under reduced pressure
3. 3
   其他the resultant residue was purified by means of silica gel column chromatography (silica gel 10 ml, hexane/ethyl acetate (5:1), ethyl acetate, ethyl acetate/methanol (10:1))

实验过程

Compound 7 (53.7 mg, 0.142 mmol) was dissolved in methanol (1.90 ml), and 28% aqueous ammonia (1.30 ml) was added to the resultant solution, followed by stirring at room temperature for 30 minutes. The resultant reaction mixture was concentrated under reduced pressure, and then the resultant residue was purified by means of silica gel column chromatography (silica gel 10 ml, hexane/ethyl acetate (5:1), ethyl acetate, ethyl acetate/methanol (10:1)), to thereby yield compound 8 (30.2 mg, 0.10 mmol, 72.3%).

来源