反应 #1929022

反应方程式

Benzoyl chloride

3-Nitrophenol

triethylamine

water

→

3-nitrophenyl benzoate

收率 90.3%

溶剂

dichloromethane

反应条件

后处理

1. 1
   workup.STIRRINGthe resulting solution was shaken at room temperature until full conversion
2. 2
   干燥The organic phase was dried over magnesium sulfate
3. 3
   过滤filtered
4. 4
   其他the solvent was removed under reduced pressure

实验过程

3-Nitrophenol (1.716 g, 12.346 mmol) and triethylamine (1.6 mL, 12.346 mmol) were dissolved in 50 mL of dichloromethane. The solution was shaken 30 minutes at room temperature. Benzoyl chloride (1.43 mL, 12.346 mmol) was added drop by drop and the resulting solution was shaken at room temperature until full conversion as determined by thin-layer chromatography. Carbonated water (20 mL) was added three times. The organic phase was dried over magnesium sulfate, filtered and the solvent was removed under reduced pressure, thus affording 2.7080 g of a white solid corresponding to 3-nitrophenyl benzoate (11.144 mmol, yield=90%).

来源