反应 #1929003

反应方程式

Sodium borohydride

( 28 )

N-benzyl-3-azabicyclo[3.3.1]nonane-9-one

→

crude compound ( 29 )

收率 191.5%

N-benzyl-3-azabicyclo[3.3.1]nonane-9-ol

收率 191.5%

N-benzyl-3-azabicyclo[3.3.1]nonane-9-one

溶剂

MeOH

反应条件

后处理

1. 1
   温度with chilling on ice
2. 2
   温度with chilling on ice, its solvent
3. 3
   其他was evaporated under reduced pressure
4. 4
   workup.ADDITIONWater was added to its residue, which
5. 5
   萃取was then subjected to extraction with methylene chloride
6. 6
   干燥by drying its organic layer with anhydrous magnesium sulfate
7. 7
   其他Its solvent was evaporated under reduced pressure

实验过程

N-benzyl-3-azabicyclo[3.3.1]nonane-9-one (28) was synthesized according to a method described in J. Med. Chem. 1994, 37, 2831-2840. Sodium borohydride (1.49 g) was added into the MeOH (80 ml) solution of (28) (6.75 g) with chilling on ice. After its mixture was stirred for 1 hour with chilling on ice, its solvent was evaporated under reduced pressure. Water was added to its residue, which was then subjected to extraction with methylene chloride, followed by drying its organic layer with anhydrous magnesium sulfate. Its solvent was evaporated under reduced pressure to produce a crude compound (29) (6.52 g).

来源