反应 #1927

反应方程式

methyl 3-bromomethyl-2-thiophenecarboxylate

triphenylphosphine

→

2-methoxycarbonylthiophen-3-ylmethyltriphenylphosphonium bromide

收率 70.4%

溶剂

toluene

反应条件

后处理

1. 1
   过滤The precipitated crystals were collected by filtration
2. 2
   其他dried

实验过程

To a solution of methyl 3-bromomethyl-2-thiophenecarboxylate (7.31 g, 31.1 mmol) in toluene (90 ml) was added triphenylphosphine (7.92 g, 30.2 mmol) under ice cooling. The temperature of the mixture was raised to room temperature, followed by stirring for 2 days. The precipitated crystals were collected by filtration and dried to give 2-methoxycarbonylthiophen-3-ylmethyltriphenylphosphonium bromide (10.57 g, 70.4%). This product was subjected to the reaction of Reference Example 13 without purification.

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