反应 #1914880

反应方程式

2,4-diamino-6-bromomethylpyrido[3,2-d]pyrimidine hydrobromide

carbazole

N-[(2,4-diaminopteridin-6-yl)methyl]-N,N-diphenylamine

NaH

→

N-[(2,4-Diaminopyrido[3,2-d]pyrimidin-6-yl)methyl]carbazole

反应条件

后处理

1. 1
   其他The product can be purified by chromatography

实验过程

N-[(2,4-Diaminopyrido[3,2-d]pyrimidin-6-yl)methyl]carbazole (Formula I: Ar=2,4-diaminopyrido[2,3-d]pyrimidin-6-yl; W=CH2; X=N; Z=chemical bond; m=n=0) is prepared similarly to N-[(2,4-diaminopteridin-6-yl)methyl]-N,N-diphenylamine as disclosed above by using carbazole (129 mg, 0.77 mmol), NaH (50 mg, 2.1 mmol), and 2,4-diamino-6-bromomethylpyrido[3,2-d]pyrimidine hydrobromide (100 mg, 0.3 mmol). The product can be purified by chromatography.

来源