反应 #1914875

反应方程式

2,4-diamino-6-bromomethylpteridine hydrobromide

MeOH

NaH

phenoxazine

NaH

→

N-[(2,4-diaminopteridin-6-yl)methyl]phenoxazine

溶剂

THF

反应条件

后处理

1. 1
   其他to come to room temperature
2. 2
   workup.WAITleft
3. 3
   浓缩the mixture was concentrated to dryness by rotary evaporation

实验过程

NaH (60% oil suspension containing 51 mg, 2.0 mmol) was added to a stirred solution of phenoxazine (147 mg, 0.784 mmol) in dry THF (10 mL) at 0° C. under N2. After 10 min. 2,4-diamino-6-bromomethylpteridine hydrobromide (100 mg, 0.392 mmol) was added and the reaction mixture was allowed to come to room temperature and left to stir for 2 days. The excess NaH was decomposed with MeOH (1 mL), and the mixture was concentrated to dryness by rotary evaporation. Flash chromatography on silica gel yielded the title compound, N-[(2,4-diaminopteridin-6-yl)methyl]phenoxazine, as a brown solid; yield 47 mg (34%); mp >250° C. dec. Anal. Calcd. for C19H15N7O0.4H2O: C, 62.60; H, 4.37. Found: C, 62.84; H, 4.10.

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