反应 #1914864

反应方程式

5,6,7,8-tetrahydro-[1,8]naphthyridine-2-carbaldehyde

(carbethoxymethylene)triphenylphosphorane

→

4-8

3-(5,6,7,8-Tetrahydro-[1,8]naphthyridin-2-yl)-acrylic acid ethyl ester

溶剂

toluene

反应条件

后处理

1. 1
   温度to reflux for 4 hours
2. 2
   其他removal of the solvent
3. 3
   其他the residue was chromatographed (silica gel, 50% EtOAc/hexanes)

实验过程

A solution of 5,6,7,8-tetrahydro-[1,8]naphthyridine-2-carbaldehyde (4-7, 2 g, 12.34 mmol) and (carbethoxymethylene)triphenylphosphorane (4.3 g, 12.34 mmol) in toluene (60 mL) was heated to reflux for 4 hours and stirred at ambient temperature for 12 hours. Following evaporative removal of the solvent, the residue was chromatographed (silica gel, 50% EtOAc/hexanes) to give 4-8 as a yellow solid.

来源