反应 #1914862

反应方程式

NaHCO3

4-4

3-(2-Methyl-pyrimidin-5-yl)-pent-4-enoic acid ethyl ester

9-BBN

→

4-5

5-Hydroxy-3-(2-methyl-pyrimidin-5-yl)-pentanoic acid ethyl ester

溶剂

THF

反应条件

后处理

1. 1
   萃取The mixture was extracted with CHCl3
2. 2
   洗涤washed with brine
3. 3
   干燥dried over MgSO4
4. 4
   其他removal of the solvent
5. 5
   其他the residue was chromatographed (silica gel, 3% EtOH/EtOAc)

实验过程

To a stirred solution of 4-4 (422 mg, 1.92 mmol) in THF was added 5.75 mL of 9-BBN (0.5 M/THF). After 18 hours, a slurry of NaBO3 (2.35 g) and NaHCO3 (2.42 g) in H20 (10 mL) was added and the mixture stirred vigorously for 1 hour. The mixture was extracted with CHCl3, washed with brine, and dried over MgSO4. Following evaporative removal of the solvent, the residue was chromatographed (silica gel, 3% EtOH/EtOAc) to give 4-5 as a clear oil.

来源