反应 #1914858

反应方程式

naphthyridine

3-Cyclopropyl-[1,8]naphthyridin-2-ol

POCl3

→

desired compound 2-5

2-Chloro-3-cyclopropyl-[1,8]naphthyridine

溶剂

DMF

反应条件

后处理

1. 1
   浓缩concentrated
2. 2
   workup.ADDITIONThe residue was treated with 300 mL ice-water and solid K2CO3 until pH=9
3. 3
   萃取The mixture was extracted three times with ethyl acetate
4. 4
   洗涤washed with brine
5. 5
   干燥dried over MgSO4
6. 6
   其他After solvent removal

实验过程

A mixture of naphthyridine 2-4 (14 g, 77 mmol) and 100 mL POCl3 and 0.1 mL DMF was refluxed at 120° C. for 3 hr and concentrated. The residue was treated with 300 mL ice-water and solid K2CO3 until pH=9. The mixture was extracted three times with ethyl acetate, washed with brine and dried over MgSO4. After solvent removal, the desired compound 2-5 was obtained as a yellowish solid.

来源