反应 #1914855

反应方程式

MNNG

diethyl ether

KOH

6-oxo-heptanoic acid

→

ester

6-Oxo-heptanoic acid methyl ester

溶剂

CH2Cl2

反应条件

后处理

1. 1
   其他The solution was purged with argon for 30 minutes
2. 2
   浓缩concentrated

实验过程

To a rapidly stirred mixture of diethyl ether (175 ml) and 40% KOH (52 ml) at 0° C. was added MNNG (15.4 g, 105 mmol). The mixture was stirred for 10 minutes. The ethereal layer was transferred to a solution of 6-oxo-heptanoic acid 1-1 (5.0 g, 34.68 mmol) and CH2Cl2 at 0° C. The solution was purged with argon for 30 minutes and then concentrated. Flash chromatography (silica, 30–50% EtOAc/hexanes) gave ester 1-2 as a clear oil.

来源