反应 #1914849

反应方程式

3-chloro-5-methoxybenzaldehyde

3-Chloro-5-methoxybenzaldehyde

Boron tribromide

H2O

→

sub-title compound

收率 25.0%

3-Chloro-5-hydroxybenzaldehyde

收率 25.0%

溶剂

CH2Cl2

反应条件

后处理

1. 1
   萃取The solution was then extracted with Et2O (2×100 mL)
2. 2
   干燥dried (Na2SO4)
3. 3
   过滤filtered
4. 4
   浓缩concentrated in vacuo

实验过程

A solution of 3-chloro-5-methoxybenzaldehyde (22.8 g, 134 mmol; see step (i) above) in CH2Cl2 (250 mL) was cooled to 0° C. Boron tribromide (15.8 mL, 167 mmol) was added dropwise over 15 min. After stirring, the reaction mixture for 2 h, H2O (50 mL) was added slowly. The solution was then extracted with Et2O (2×100 mL). The organic layers were combined, dried (Na2SO4), filtered and concentrated in vacuo. Flash chromatography on silica gel eluting with Hex:EtOAc (4:1) afforded the sub-title compound (5.2 g, 25%).

来源