反应 #1909787

反应方程式

3,4-dichloro-2,4-dihydroxybenzoic acid

L-phenylalanine methyl ester hydrochloride

WSC.HCl

HOBT

→

title compound

收率 63.1%

N-(3,5-Dichloro-2,4-dihydroxybenzoyl)-L-phenylalanine methyl ester

收率 63.1%

溶剂

DMF

triethylamine

反应条件

后处理

1. 1
   workup.ADDITIONThen, the mixture was post-treated in the same manner as in the above Example 1, (Step 5)

实验过程

To a solution of 3,4-dichloro-2,4-dihydroxybenzoic acid (17 g), L-phenylalanine methyl ester hydrochloride (19.8 g), WSC.HCl (17.6 g) and HOBT (12.4 g) in DMF (70 ml) was added dropwise triethylamine (12.8 ml) at room temperature, and the mixture was stirred for 16 hours. Then, the mixture was post-treated in the same manner as in the above Example 1, (Step 5) to give the title compound (18.32 g, yield 57%).

来源