反应 #1909786

反应方程式

L-phenylalaninol

sodium hydride

benzyl bromide

→

title compound

收率 77.0%

O-Benzyl-L-phenylalaninol

收率 77.0%

溶剂

THF

brine

反应条件

后处理

1. 1
   其他at room temperature
2. 2
   温度Twenty minutes later, the reaction mixture was refluxed
3. 3
   温度under heating for 1 hour
4. 4
   温度to cool
5. 5
   温度cooling
6. 6
   萃取extracted with ether
7. 7
   萃取The organic layer was extracted with 10% hydrochloric acid
8. 8
   萃取extracted with ether
9. 9
   洗涤The organic layer was washed with saturated brine
10. 10
    干燥dried over anhydrous magnesium sulfate
11. 11
    浓缩concentrated under reduced pressure

实验过程

To a solution of L-phenylalaninol (11.78 g) in THF (200 ml) was gradually added 60% sodium hydride (3.43 g) in oil at room temperature. Twenty minutes later, the reaction mixture was refluxed under heating for 1 hour. Then, the mixture was allowed to cool, followed by gradual addition of benzyl bromide (9.27 ml) under ice-cooling, and stirred at room temperature for 16 hours. The reaction mixture was added to saturated brine, and extracted with ether. The organic layer was extracted with 10% hydrochloric acid. The aqueous layer was made alkaline with an aqueous sodium hydroxide solution, and extracted with ether. The organic layer was washed with saturated brine, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure to give the title compound (14.5 g, yield 77%).

来源