反应 #1904566

反应方程式

Water

2-acetyl thiazole

hydroxylamine hydrochloride

Pyridine

→

title compound

收率 88.0%

1-(1,3-Thiazol-2-yl)-1-ethanone oxime

收率 88.0%

溶剂

ethanol

反应条件

后处理

1. 1
   其他to prepare a solution
2. 2
   萃取the mixture was extracted three times with ethyl acetate
3. 3
   洗涤The organic layer was washed with water
4. 4
   干燥was dried over sodium sulfate
5. 5
   其他The solvent was removed by evaporation
6. 6
   其他was dried by means of a vacuum pump

实验过程

Commercially available 2-acetyl thiazole (1.27 g) and commercially available hydroxylamine hydrochloride (830 mg) were dissolved in ethanol (40 ml) to prepare a solution. Pyridine (0.97 ml) was added to the solution, and the mixture was stirred at room temperature overnight. Water was added to the reaction solution, and the mixture was extracted three times with ethyl acetate. The organic layer was washed with water and was dried over sodium sulfate. The solvent was removed by evaporation and was dried by means of a vacuum pump to give the title compound (1.25 g, 88%).

来源