反应 #1904038

反应方程式

aspartic acid

triethyl amine

succinyl chloride

→

Aspartic Acid Succinimide

溶剂

tetrahydrofuran

反应条件

后处理

1. 1
   其他fitted with a condenser and nitrogen inlet
2. 2
   温度refluxed for 6 hours
3. 3
   过滤The triethyl amine hydrochloride is filtered
4. 4
   浓缩the filtrate is concentrated
5. 5
   其他by removing the solvent under vacuum
6. 6
   其他The residue is used directly for the subsequent reaction
7. 7
   其他The residue can be purified by chromatography on silica gel

实验过程

This example that demonstrates how this method could be performed. 9.4 g aspartic acid, 10 ml triethyl amine and 100 ml tetrahydrofuran are transferred into a 100 ml flask fitted with a condenser and nitrogen inlet. The mixture is cooled to 0° C. and 5 g succinyl chloride is added and the mixture stirred under nitrogen atmosphere for 5 min and refluxed for 6 hours. The triethyl amine hydrochloride is filtered and the filtrate is concentrated by removing the solvent under vacuum. The residue is used directly for the subsequent reaction. The residue can be purified by chromatography on silica gel.

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