反应 #1904

反应方程式

2-amino-4'-benzyloxy-5-chloro-2'-methoxybenzophenone

sodium borohydride

→

2-amino-α-(4-benzyloxy-2-methoxyphenyl)-5-chlorobenzyl alcohol

收率 94.5%

溶剂

methanol

反应条件

后处理

1. 1
   浓缩the mixture was concentrated in vacuo
2. 2
   workup.ADDITIONThe residue was diluted with water (200 ml)
3. 3
   萃取extracted with ethyl acetate (300 ml)
4. 4
   洗涤The extract was washed with water
5. 5
   干燥dried over magnesium sulfate
6. 6
   浓缩concentrated in vacuo
7. 7
   其他The residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1-2:1)

实验过程

To a solution of 2-amino-4'-benzyloxy-5-chloro-2'-methoxybenzophenone (10 g) in methanol (100 ml) was added sodium borohydride (1.4 g). After being stirred for 24 h, the mixture was concentrated in vacuo. The residue was diluted with water (200 ml) and extracted with ethyl acetate (300 ml). The extract was washed with water, dried over magnesium sulfate and concentrated in vacuo. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1-2:1) to give 2-amino-α-(4-benzyloxy-2-methoxyphenyl)-5-chlorobenzyl alcohol (9.5 g) as colorless crystals (mp=101°-103° C.).

来源