反应 #1889

反应方程式

2-amino-5-chloro-α-(2-chlorophenyl)benzyl alcohol

trifluoroacetic acid

sodium hydrogen carbonate

→

crystal

收率 95.7%

5-chloro-α-(2-chlorophenyl)-2-(trifluoroacetylamino)benzyl alcohol

收率 95.7%

溶剂

dichloromethane

dichloromethane

反应条件

后处理

1. 1
   其他After reaction
2. 2
   其他the organic layer was dried
3. 3
   其他after which the solvent was removed
4. 4
   其他the residue was recrystallized from hexane

实验过程

To a solution of 1.0 g of 2-amino-5-chloro-α-(2-chlorophenyl)benzyl alcohol in 12 ml of dichloromethane, a solution of 0.8 g of anhydrous trifluoroacetic acid in 2 ml of dichloromethane was added. After reaction, an aqueous solution of sodium hydrogen carbonate was added, and the organic layer was dried, after which the solvent was removed and the residue was recrystallized from hexane to yield 1.3 g of a crystal.

来源