反应 #1887

反应方程式

sodium cyanoborohydride

2-amino-5-chloro-α-(2,4,6-trimethoxyphenyl)benzyl alcohol

trimethylacetaldehyde

acetic acid

→

crystal

5-chloro-α-(2,4,6-trimethoxyphenyl)-2-(neopentylamino)benzyl alcohol

溶剂

ethanol

反应条件

后处理

1. 1
   浓缩After concentration and subsequent dilution with water
2. 2
   萃取the solution was extracted with ethyl acetate
3. 3
   其他After solvent removal

实验过程

After a solution of 2.5 g of 2-amino-5-chloro-α-(2,4,6-trimethoxyphenyl)benzyl alcohol, 1.01 ml of trimethylacetaldehyde and 0.56 g of acetic acid in 30 ml of ethanol was stirred at room temperature for 1.5 hours, 0.81 g of sodium cyanoborohydride was added, followed by stirring overnight. After concentration and subsequent dilution with water, the solution was extracted with ethyl acetate. After solvent removal, the residue was subjected to silica gel column chromatography to yield 2.2 g of a crystal.

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