反应 #1885090

反应方程式

6,7-difluoro-4-hydroxy quinoline

Ethyl 6,7-difluoro-4-hydroxy-2-methyl-quinoline-3-carboxylate

phosphorus oxychloride

ammonia

→

Ethyl 4-chloro-6,7-difluoro-2-methyl-quinoline-3-carboxylate

反应条件

后处理

1. 1
   其他To the cooled reaction mixture
2. 2
   其他the product was obtained
3. 3
   萃取by extracting with methylene chloride
4. 4
   干燥dried over sodium sulfate
5. 5
   浓缩concentrated in vacuo

实验过程

A suspension of 6,7-difluoro-4-hydroxy quinoline 2i was refluxed with phosphorus oxychloride for 30 minutes. To the cooled reaction mixture was added aqueous ammonia and the product was obtained by extracting with methylene chloride, dried over sodium sulfate and concentrated in vacuo. 1H NMR (CDCl3) δ (ppm): 1.44 (3H, t, J=7.14 Hz), 2.70 (3H, s), 4.50 (2H, q, J=7.14 Hz), 7.62 (1H, t, J=7.69 Hz), 7.78 (1H, dd, J=10.71, 7.69 Hz), 7.95 (2H, d, J=10.72, 8.24 Hz). m/z 286.7 (MH+).

来源