反应 #1885088

反应方程式

3a

Ethyl 4-chloro-quinoline-3-carboxylate

2h

Ethyl 4-hydroxy-6-trifluoromethyl-quinoline-3-carboxylate

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title compound

Ethyl 4-chloro-6-trifluoromethyl-quinoline-3-carboxylate

反应条件

实验过程

The title compound was prepared following the procedure described in Step 2 for the synthesis of 3a using 2h instead of 2a. 1H NMR (CDCl3) δ (ppm): 1.46 (3H, t, J=7.14 Hz), 4.51 (2H, q, J=7.14 Hz), 8.00 (1H, dd, J=8.79, 1.92 Hz), 8.26 (1H, d, J=8.79 Hz), 8.78 (1H, dd, J=1.92, 0.83 Hz), 9.34 (1H, s). m/z 304.6 (MH+).

来源