反应 #1885079

反应方程式

4a

2-Phenyl-2,5-dihydro-pyrazolo-(4,3-c) quinolin-3-one

3b

Ethyl 4-chloro-6-fluoro-quinoline-3-carboxylate

phenyl hydrazine

→

title compound

8-Fluoro-2-phenyl-2,5-dihydro-pyrazolo-(4,3-c)quinolin-3-one

反应条件

实验过程

The title compound was prepared following the procedure described in Step 3 of the synthesis of 4a, using 3b and phenyl hydrazine. 1H NMR (DMSO-d6) δ (ppm):7.16 (1H, t, J=13.67 Hz), 7.41 (2H, t, J=7.56 Hz), 7.55 (1H, dt, J=8.54, 2.93 Hz), 7.77 (1H, dd, J=9.27, 4.88 Hz), 7.90 (1H, dd, J=9.27, 2.93 Hz), 8.18 (2H, dd, J=7.58, 1.95 Hz), 8.73 (1H, s). m/z 280.5 (MH+).

来源