反应 #1885072

反应方程式

2-phenylaminomethylene-malonic acid diethyl ester

→

ethyl 4-hydroxy-quinoline-3-carboxylate

Ethyl 4-hydroxy-quinoline-3-carboxylate

溶剂

Dowtherm

反应条件

后处理

1. 1
   过滤solid was collected by filtration
2. 2
   洗涤washed with hexane

实验过程

The 2-phenylaminomethylene-malonic acid diethyl ester was refluxed in Dowtherm® for 15 min to 2 h. The reaction mixture was cooled to 80° C. and solid was collected by filtration and washed with hexane to yield crude ethyl 4-hydroxy-quinoline-3-carboxylate 2a which was used in next step without further purification.

来源