反应 #1885071

反应方程式

Dichloromethane

4-(2-oxo-2,3-dihydrobenzimidazol-1-yl)butyric acid

oxalyl chloride

→

chloro 2,3-dihydro-2-oxo-1H-benzimidazol-1-butanoate

溶剂

N,N-dimethylformamide

反应条件

后处理

1. 1
   workup.STIRRINGThe resulting mixture was then stirred at 15-20° C. for an additional 1-3 hours

实验过程

Dichloromethane (3772 L) and then 4-(2-oxo-2,3-dihydrobenzimidazol-1-yl)butyric acid (525 kg; 2.4 kmol) were charged to a stirred-tank reactor, followed by N,N-dimethylformamide (21 L). The resulting mixture was cooled to 10° C. Afterward, oxalyl chloride (326.8 kg)) was dosed at 10-15° C. over 2-3 hours while stirring. The resulting mixture was then stirred at 15-20° C. for an additional 1-3 hours. All the above steps were conducted under a N2 atmosphere. Conversion was checked by in-process control (“IPC”).

来源