反应 #1885068

反应方程式

Formamide

compound 21

methyl 2-amino-4,5-bis(2-methoxyethoxy)benzoate

→

compound 22

6,7-bis(2-methoxyethoxy)quinazolin-4(3H)-one

溶剂

N-methyl-2-pyrrolidone

反应条件

后处理

1. 1
   其他Reaction
2. 2
   workup.ADDITIONThe reaction mixture was poured in to ice cold water and solids
3. 3
   过滤were filtered
4. 4
   其他The crude product was purified by column chromatography

实验过程

Formamide (130 mL) was added to a solution of compound 21 (13.0 g, 43.43 mmol) in N-methyl-2-pyrrolidone (130 mL) and the reaction mixture was heated to 165-170° C. under N2 for 12 h. Reaction was monitored by TLC. After 8.0 h TLC indicated no starting material. The reaction mixture was poured in to ice cold water and solids were filtered. The crude product was purified by column chromatography to give compound 22 as light yellow solid.

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