反应 #1885067

反应方程式

14

N-(3-ethynylphenyl)-6,7-diacetoxy-4-quinazolinamine hydrochloride

ammonia

→

15

收率 93.0%

N-(3-ethynylphenyl)-6,7-dihydroxy-4-quinazolinamine hydrochloride

收率 93.0%

溶剂

methanol

反应条件

后处理

1. 1
   过滤The reaction mass was filtered
2. 2
   洗涤the solid was washed with water

实验过程

To the hydrochloride salt, 14 (4.2 g, 11.62 mmol) in methanol (30 ml) was added 25% aqueous ammonia (4.73 ml) and the solution was stirred for 4 h. The reaction mass was filtered and the solid was washed with water to give the N-(3-ethynylphenyl)-6,7-dihydroxy-4-quinazolinamine hydrochloride, 15 (3.0 g, 93%) as a brownish yellow solid. 1H NMR (400 MHz, DMSO-d6): 4.2 (s, 1H), 7.10 (s, 1H), 7.17-7.19 (m, 2H), 7.34-7.39 (t, 1H), 7.79 (s, 1H), 7.87-7.89 (d, 1H), 8.05 (s, 1H), 8.45 (s, 1H), 9.4-9.6 (bs. s, 1H). MS (ESI): 278.

来源