反应 #1885065

反应方程式

NH3

6,7-dimethoxy-4(3H)-quinazolinone

10

dimethoxyquinazolinone

HBr

→

11

收率 84.0%

6,7-dihydroxy-4(3H)-quinazolinone

收率 84.0%

反应条件

后处理

1. 1
   温度the solution was heated
2. 2
   温度The reaction mixture was cooled to room temperature
3. 3
   过滤the solids were filtered
4. 4
   其他The solid obtained
5. 5
   过滤the solution was filtered
6. 6
   洗涤washed with water
7. 7
   其他dried

实验过程

To 6,7-dimethoxy-4(3H)-quinazolinone, 10 (3.0 g, 14.5 mmol) was added 48% HBr (36 mL) and the solution was heated to reflux at 100° C. for 12 h. The reaction mixture was cooled to room temperature and the solids were filtered. The solid obtained was neutralized with aq. NH3 (pH=8) and the solution was filtered and washed with water and dried to give 6,7-dihydroxy-4(3H)-quinazolinone, 11 as a off-white crystalline solid (2.20 g, 84%).

来源