反应 #1884963

反应方程式

N-tert-butyl-(3-chloro)propylsulfonamide

n-BuLi

→

desired product

收率 56.4%

Cyclopropanesulfonic Acid tert-Butylamide

收率 56.4%

溶剂

THF

反应条件

后处理

1. 1
   其他The volatiles were removed in vacuo
2. 2
   其他The residue was partitioned between EtOAC and water (200 mL, 200 mL)
3. 3
   洗涤The separated organic phase was washed with brine
4. 4
   干燥dried over Na2SO4
5. 5
   过滤filtered
6. 6
   浓缩concentrated in vacuo
7. 7
   其他The residue was recrystallized from hexane

实验过程

To a solution of N-tert-butyl-(3-chloro)propylsulfonamide (2.14 g, 10.0 mmol) in THF (100 mL) was added n-BuLi (2.5 M in hexane, 8.0 mL, 20.0 mmol) at −78° C. The reaction mixture was allowed to warm up to room temperature over period of 1 h. The volatiles were removed in vacuo. The residue was partitioned between EtOAC and water (200 mL, 200 mL). The separated organic phase was washed with brine, dried over Na2SO4, filtered and concentrated in vacuo. The residue was recrystallized from hexane to yield the desired product as a white solid (1.0 g, 56%).

来源