反应 #1880982

ord-522d9bae185e4a17a4eae62abe878679

反应方程式

CC(C)C[C@H](CN)CC(=O)O
Pregabalin
OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
lactose
CC#N
acetonitrile
→
CC(C)C[C@H](CN)CC(=O)O.OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
Pregabalin Lactose

反应物

CC(C)C[C@H](CN)CC(=O)O
Pregabalin
OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O
lactose
CC#N
acetonitrile

试剂

无

溶剂

O
water
CC(C)O
isopropyl alcohol

反应条件

温度
90°CELSIUS
详细条件
See reaction.notes.procedure_details.

后处理

  1. 1
    温度heat
  2. 2
    其他a heating block overnight
  3. 3
    其他by sonicating
  4. 4
    温度heating

实验过程

Pregabalin (0.8 g) and lactose (3.8 g) were dissolved in 5 mL of water with stirring and heat. The solution was then heated at 90° C. in an open Pyrex™ beaker using a heating block overnight. The resulting solid was then redissolved in approximately 20 mL of isopropyl alcohol by sonicating and heating. Forty milliliters of acetonitrile were added to this solution. The resulting solid was subjected to preparative scale reversed-phase chromatography.

来源

DOI: 10.6084/m9.figshare.5104873.v1专利: US07022678B2uspto-grants-2006_04