反应 #1880975

反应方程式

compound

2-(6-Pyrazol-1-yl-pyridin-3-ylmethoxy)-isoindole-1,3-dione

→

desired compound

O-(6-Pyrazol-1-yl-pyridin-3-ylmethyl)-hydroxylamine

溶剂

NH3

methanol

反应条件

后处理

1. 1
   浓缩The reaction mixture was subsequently concentrated in vacuo
2. 2
   其他purified on silica gel

实验过程

A solution of the compound of Step 7d (32 g, 0.1 mol) in 100 ml of 2M NH3 in methanol was stirred at 50° C. for 4 hours. The reaction mixture was subsequently concentrated in vacuo and purified on silica gel to give the desired compound of formula (XI) (18.5 g, 97%).

来源