反应 #1880972

反应方程式

DEAE

(R)-(+)-glycidol

phthalimide

triphenyl phosphine

→

desired product

收率 75.4%

N-(2(R), 3-Epoxypropyl)phthalimide

收率 75.4%

溶剂

THF

反应条件

后处理

1. 1
   温度under cooling on ice-bath
2. 2
   其他Molecular shieve was removed by filtration and filtrate
3. 3
   其他was evaporated to dryness in vacuo
4. 4
   其他The desired product was further purified by silica gel chromatography

实验过程

To THF solution (400 ml) of (R)-(+)-glycidol 2.47 g (32 mmol), phthalimide 7 g (47.6 mmol), triphenyl phosphine 14.3 g (54.5 mmol) and molecular shieve 4 Å 30 g were added at room temperature and then DEAE 8.7 g (50 mmol) was added dropwise under cooling on ice-bath. The reaction mixture was allowed to stand at room temperature overnight. Molecular shieve was removed by filtration and filtrate was evaporated to dryness in vacuo. The desired product was further purified by silica gel chromatography. 4.9 g of desired product was obtained as an oil. The NMR spectra were consistent with the desired title intermediate.

来源