反应 #1880969

反应方程式

N-(2-ethylbutyryl)-2(S)-pyrrolidine-carboxylic acid ethylester

NaOH

HCl

→

desired product

收率 104.6%

N-(2-Ethylbutyryl)-2(S)-pyrrolidine-carboxylic acid

收率 104.6%

溶剂

methanol

反应条件

后处理

1. 1
   温度The reaction mixture was cooled on ice-bath
2. 2
   浓缩The reaction mixture was concentrated in vacuo
3. 3
   workup.DISSOLUTIONthe residue was dissolved in chloroform
4. 4
   洗涤washed with water
5. 5
   干燥dried over anhydrous sodium sulfate
6. 6
   其他The solvents were removed in vacuo

实验过程

To methanol solution (13 ml) of N-(2-ethylbutyryl)-2(S)-pyrrolidine-carboxylic acid ethylester 1.46 g (6.05 mmol), 2N—NaOH solution (6.5 ml) was added, and stirring was continued at room temperature for 2 hours. The reaction mixture was cooled on ice-bath, and adjusted to pH2 with 6N—HCl solution. The reaction mixture was concentrated in vacuo, and the residue was dissolved in chloroform, washed with water, and then dried over anhydrous sodium sulfate. The solvents were removed in vacuo to yield 1.35 g of desired product as an oil. NMR was consistent with the desired title product.

来源