反应 #1876844

反应方程式

Oxone

4-[(2-methylthio-ethyl)-(4-fluoro-benzyl)-amino]-N-ethyl-benzenesulfonamide

H2O

→

4-[(2-methylsulfonyl-ethyl)-(4-fluoro-benzyl)-amino]-N-ethyl-benzenesulfonamide

收率 100.0%

溶剂

MeOH

反应条件

后处理

1. 1
   其他resulting in an immediate precipitate
2. 2
   其他the mixture was partitioned between CH2Cl2 and H2O
3. 3
   萃取The aqueous layer was extracted with CH2Cl2 (2×)
4. 4
   干燥The combined organic layer was dried (Na2SO4)
5. 5
   过滤filtered
6. 6
   其他evaporated in vacuo

实验过程

A solution of Oxone® (0.54 g, 0.88 mmol) in H2O (2 mL) was added to a 0° C. solution of 4-[(2-methylthio-ethyl)-(4-fluoro-benzyl)-amino]-N-ethyl-benzenesulfonamide (0.13 g, 0.34 mmol) in MeOH (8 mL) resulting in an immediate precipitate. After 1 h, the mixture was partitioned between CH2Cl2 and H2O. The aqueous layer was extracted with CH2Cl2 (2×). The combined organic layer was dried (Na2SO4), filtered, and evaporated in vacuo to afford 0.14 g (100%) of 4-[(2-methylsulfonyl-ethyl)-(4-fluoro-benzyl)-amino]-N-ethyl-benzenesulfonamide as a pale glass; (m+H)+ 415.

来源