反应 #1876841

反应方程式

BH3.THF THF

4-[(2-methylthio-ethyl)-(2-methoxy-benzoyl)-amino]-benzenesulfonamide

→

4-[(2-methylthio-ethyl)-(2-methoxy-benzyl)-amino]-benzenesulfonamide

收率 77.4%

溶剂

THF

反应条件

后处理

1. 1
   其他the excess BH3 was quenched by addition of 0.1 M HCl
2. 2
   其他by partitioning the mixture between CH2Cl2 and NaHCO3
3. 3
   干燥The organic layer was dried (Na2SO4)
4. 4
   过滤filtered
5. 5
   其他evaporated in vacuo
6. 6
   其他the residue was purified by MPLC (CH2Cl2 to 70:30 CH2Cl2/EtOAc)

实验过程

A solution of 1 M BH3.THF/THF (6.8 mL, 6.8 mmol) was added to a solution of 4-[(2-methylthio-ethyl)-(2-methoxy-benzoyl)-amino]-benzenesulfonamide (0.51 g, 1.34 mmol) in THF (5 mL). After 18 h, the excess BH3 was quenched by addition of 0.1 M HCl; followed by partitioning the mixture between CH2Cl2 and NaHCO3. The organic layer was dried (Na2SO4), filtered, evaporated in vacuo, and the residue was purified by MPLC (CH2Cl2 to 70:30 CH2Cl2/EtOAc) to afford 0.38 g (77%) of 4-[(2-methylthio-ethyl)-(2-methoxy-benzyl)-amino]-benzenesulfonamide as a clear glass.

来源