反应 #1876839

反应方程式

2-bromo-5-nitropyridine

sodium thiomethoxide

→

2-methylthio-5-nitro-pyridine

收率 67.4%

溶剂

DMF

反应条件

后处理

1. 1
   其他partitioned between ethyl acetate and water
2. 2
   干燥dried over MgSO4
3. 3
   浓缩concentrated

实验过程

To a solution of 2.0 g (9.85 mmol) 2-bromo-5-nitropyridine dissolved in 8 mL DMF was added 690 mg (9.85 mmol) of sodium thiomethoxide. The mixture was stirred at room temperature for 1 h, and partitioned between ethyl acetate and water, dried over MgSO4 and concentrated to obtain 1.13 g of 2-methylthio-5-nitro-pyridine, pure by 1H NMR.

来源