反应 #1876838

反应方程式

4-[(4-methyl-benzyl)-amino]-[N,N-bis(4-methoxy-benzyl)]-benzenesulfonamide

methylvinyl sulfone

sodium hydride

→

4-[(2-methylsulfonyl-ethyl)-(4-methyl-benzyl)-amino]-[N,N-bis(4-methoxy-benzyl)]-benzenesulfonamide

收率 75.1%

溶剂

DMF

反应条件

后处理

1. 1
   workup.ADDITIONwere added
2. 2
   其他partitioned between ethyl acetate and water
3. 3
   干燥dried over MgSO4
4. 4
   其他purified by column chromatography
5. 5
   洗涤eluting with 1:4 acetone/hexane

实验过程

4-[(4-methyl-benzyl)-amino]-[N,N-bis(4-methoxy-benzyl)]-benzenesulfonamide (1.03 g, 2.6 mmol) was dissolved in 6 mL of DMF at room temperature, to which methylvinyl sulfone (0.175 mL, 2.0 mmol) and sodium hydride (95%, 60 mg, 2.4 mmol) were added. The reaction was stirred at room temperature for 1.5 h, partitioned between ethyl acetate and water, dried over MgSO4 and purified by column chromatography, eluting with 1:4 acetone/hexane, to provide 935 mg of 4-[(2-methylsulfonyl-ethyl)-(4-methyl-benzyl)-amino]-[N,N-bis(4-methoxy-benzyl)]-benzenesulfonamide.

来源